{"id":99378,"date":"2021-07-25T12:22:03","date_gmt":"2021-07-25T17:22:03","guid":{"rendered":"https:\/\/08b67ef4d4.nxcli.io\/?p=99378"},"modified":"2021-07-25T12:35:55","modified_gmt":"2021-07-25T17:35:55","slug":"disease","status":"publish","type":"post","link":"https:\/\/nouvelleresearch.com\/index.php\/articles\/99378-disease","title":{"rendered":"Disease, Injury and Mitochondrial Dysfunction"},"content":{"rendered":"<p>Back in the days of high school biology class, we all learned the components of the cell.\u00a0 Chances are that most of us have forgotten what we learned back then and that is okay, but in today&#8217;s medical society this knowledge is becoming important whether it is our health or that of our pets and horses. Cellular health is the ultimate goal with any equine related problem, whether if that is a medical condition or a lameness.\u00a0 Going deeper, in truth, it is all about the mitochondria within those cells, how well it is functioning, and the overall health of the organism.\u00a0 This mitochondrial function is what determines health and soundness in your horse.<\/p>\n<p><strong><span style=\"color: red;\">Mitochondria and Energy<\/span><\/strong><br \/>\nOne of the most important components of the cell is the mitochondria, which the name may ring a bell.\u00a0 The mitochondria has been termed the &#8220;Power House of the Cell&#8221; because it is the main source of energy production in the form of ATP.\u00a0 Every cell in the body, with the exception of the red blood cell, has a mitochondria and actually, the number of mitochondria contained in a given cell varies dependent on the type of cell we are talking about.\u00a0 Some have more and some have fewer, it is really dependent on the nature of the cell and energy output required.\u00a0 Muscle and nervous tissue require more energy and thus usually have more mitochondria per cell.<\/p>\n<div class=\"separator\" style=\"clear: both; text-align: center;\"><a style=\"clear: right; float: right; margin-bottom: 1em; margin-left: 1em;\" href=\"https:\/\/nouvelleresearch.com\/\/\/wp-content\/uploads\/2013\/07\/3.bp.blogspot.com_-hyrhNOJ18YM_UapK9-3HWVI_AAAAAAAAAGs_1u1Eg2kBSiI_s1600_iStock_000012095049Small.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\" alignright size-full wp-image-567\" src=\"https:\/\/nouvelleresearch.com\/\/\/wp-content\/uploads\/2013\/07\/3.bp.blogspot.com_-hyrhNOJ18YM_UapK9-3HWVI_AAAAAAAAAGs_1u1Eg2kBSiI_s200_iStock_000012095049Small.jpg\" alt=\"\" width=\"199\" height=\"200\" \/><\/a><\/div>\n<p>The mitochondria is also involved in many other aspects of cellular function, including cell signaling, cellular differentiation as well as cell growth.\u00a0 Most of these aspects or jobs are dependent on the presence of energy or ATP and when that is impacted, they cannot perform their other jobs.<\/p>\n<p>The process of energy or ATP production within the mitochondria is complicated but is essentially dependent on the shifting of protons across membranes and the creation of a proton gradient.\u00a0 This process depends on the presence of many enzymes, co-factors and nutrients to function smoothly.\u00a0 One main component needed is oxygen as well as glucose.\u00a0 The process of energy production in the presence of oxygen is termed cellular aerobic respiration.\u00a0 If oxygen is not present or in low levels, the energy production will shift outside of the mitochondria and result in anaerobic respiration with lactic acid production.\u00a0 Excessive lactic acid production creates the burn in the muscles that we feel when exercising intensely. One interesting thing to note is that an end product of ATP production by the mitochondria are free radicals such as superoxide and hydrogen peroxide, which results in oxidative stress.\u00a0 This oxidative stress can then inflict damage to the mitochondria itself, resulting in cellular malfunction.<\/p>\n<p><span style=\"color: red;\"><strong>Dysfunction &amp; Disease<\/strong><\/span><br \/>\nMitochondrial disease is connected with many conditions affecting humans as well as animals including:<\/p>\n<ul>\n<li>cardiovascular disease\/ arrhythmias<\/li>\n<li>respiratory conditions<\/li>\n<li>neuromuscular disease<\/li>\n<li>gastrointestinal problems<\/li>\n<li>immune system disorders<\/li>\n<li>diabetes\/insulin resistance<\/li>\n<li>exercise intolerance\/ fatigue<\/li>\n<li>joint deterioration\/tendon injuries<\/li>\n<li>cancer<\/li>\n<li>overall tissue weakness and predisposition to injury<\/li>\n<\/ul>\n<p>Actually, any time there is a problem in the body, whether if it is a disease or ongoing injury, it can be traced back to poorly functioning mitochondria. A cell requires energy to be produced to function correctly and if there is no energy being produced, then the cell malfunctions.<\/p>\n<p>Malfunction of the mitochondria is directly associated with genetic mutation to some level, which can be acquired or inherited.\u00a0 Many mitochondrial diseases are inherited on a genetic level, while others are actually induced or acquired as a result of ongoing uncontrolled oxidative stress, dietary influences, medications, toxins, lifestyle influences and many other factors.\u00a0 The bottom line end result is that if the mitochondria is not functioning correctly, then cellular function is impaired on multiple levels. This can result in disease formation, joint deterioration, poor performance and even just a predisposition to injury.\u00a0 The resultant poor functioning mitochondria actually then triggers the activation of a transcription factor (NF-kB) which results in the production of inflammatory proteins such as interleukins, prostaglandins, MMP&#8217;s and a host of others.\u00a0 These inflammatory proteins then contribute to a host of conditions including joint deterioration, cancer, respiratory conditions&#8230;.the list goes on and on, but they themselves feedback and injure the mitochondria.\u00a0 It becomes a vicious cycle.<\/p>\n<p>Mitochondrial dysfunction is also present when injuries occur such as a strained ligament, tendon or muscle group.\u00a0 First, those cells were likely predisposed to injury due to ongoing low level cellular malfunction.\u00a0 Second, when that tissue is injured, it needs to repair itself through cellular differentiation and growth, all of which are regulated by the mitochondria.\u00a0 If mitochondrial function is poor, not only will injuries be more likely but those same injuries may take excessive time to heal or never recover.<\/p>\n<p><span style=\"color: red;\"><strong>Prevention &amp; Treatment <\/strong><\/span><br \/>\nSo, what can we do to improve mitochondrial function?\u00a0 There are many factors we can control including diet,lifestyle influences and stressors that may aid in their function.\u00a0 We can also try to minimize the exposure to various toxins, which includes vaccines.\u00a0 Over vaccinating is an issue in my opinion and can be tapered back in many instances without causing increased risk to the patient. Minimizing excessive prescription drug use can also play a role in maintaining healthy mitochondrial function as many medications can create problems indirectly.\u00a0 The other main factor that we need to keep in mind is that with energy production (ATP) comes oxidative stress.\u00a0 It is a part of doing business, but fortunately something that can be controlled.\u00a0 People and animals that are worked or exercised heavily create an increased demand on their mitochondria for energy production.\u00a0 Unfortunately, with this comes a higher level of free radicals being produced which then contribute to mitochondrial dysfunction.\u00a0<strong> This may explain why some athletes (human or animal) are at more risk for injury and joint deterioration, not to mention breakdowns<\/strong>.<\/p>\n<div class=\"separator\" style=\"clear: both; text-align: center;\"><a style=\"clear: left; float: left; margin-bottom: 1em; margin-right: 1em;\" href=\"https:\/\/nouvelleresearch.com\/\/\/wp-content\/uploads\/2013\/07\/3.bp.blogspot.com_-0lPHprNrOwM_UapLyoBaSeI_AAAAAAAAAG8_vUpdxmTSj4Y_s1600_img_product%20-%20Copy.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\" alignleft size-full wp-image-568\" src=\"https:\/\/nouvelleresearch.com\/\/\/wp-content\/uploads\/2013\/07\/3.bp.blogspot.com_-0lPHprNrOwM_UapLyoBaSeI_AAAAAAAAAG8_vUpdxmTSj4Y_s1600_img_product%20-%20Copy.jpg\" alt=\"\" width=\"238\" height=\"192\" \/><\/a><\/div>\n<p><strong>We can prevent, manage and improve mitochondrial function through two simple avenues:<\/strong><br \/>\n<strong>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 1.\u00a0\u00a0 Specific Antioxidant Therapy<\/strong><br \/>\n<strong>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 2.\u00a0\u00a0 Complete Inflammation Control<\/strong><\/p>\n<p>Antioxidants come in many forms, some we are familiar with and some not so much.\u00a0 Vitamin C and vitamin E are too commonly recognized antioxidants.\u00a0 Vitamin E is commonly used in horses with neuromuscular problems and the reason is that it tends to aid the mitochondria in nerve and muscle cells by neutralizing free radicals.\u00a0\u00a0 Another important antioxidant is CoQ10, which is directly involved with the production of ATP in the mitochondria.\u00a0 Many conditions of mitochondrial dysfunction are directly tied to low cellular levels of CoQ10.<\/p>\n<p>We cannot forget the other arm of mitochondrial protection and that is through inflammation reduction.\u00a0 Many herbs are antioxidants as well, including curcumin and boswellia, which not only combat the free radicals but also have the added benefit in that they aid in the reduction of the inflammatory arm of the cascade by reducing inflammatory proteins.\u00a0 Curcumin has been shown to directly impact mitochondrial function as well as improve cellular antioxidant levels.\u00a0 It is one of the most important herbs for mitochondrial health, but must be taken at specific doses to yield benefits.\u00a0 All of our <strong><span style=\"color: blue;\"><a href=\"https:\/\/nouvelleresearch.com\/\" target=\"_blank\" rel=\"noopener\">Cur-OST<\/a><\/span><\/strong> products take advantage of the synergism between herbal anti-inflamamtories and antioxidants to achieve these results.<\/p>\n<p>The bottom line is that we can do a lot to improve cellular health and function, through the use of natural occurring antioxidants and anti-inflammatories.\u00a0 Prescription anti-inflammatories generally combat a small part of the inflammatory process and do nothing to improve mitochondrial function.\u00a0 They are essentially band-aids and are not addressing the bottom line problem.\u00a0 If you want more energy for yourself, your pets or your horse or are looking to reduce injuries and prevalence of disease&#8230;. you want to protect and enhance the mitochondria. By improving and protecting mitochondrial function, we can improve overall performance, slow degeneration and reduce injury.<\/p>\n<p>Our goal at<span style=\"color: blue;\"><strong> <a href=\"https:\/\/nouvelleresearch.com\/\" target=\"_blank\" rel=\"noopener\">Nouvelle Research, Inc<\/a><\/strong><\/span>. has always been to impact health through inflammation reduction and antioxidant support.\u00a0 The process is complicated but by reducing this inflammatory process on a consistent basis, we can protect the cells from deterioration, slow progression of many diseases, reduce pain and encourage normal tissue repair. Inflammation and oxidative stress are a normal part of all of our daily lives, whether if we are human or animal.\u00a0 Certain conditions such as stress due to lifestyle or even trailering worsen the situation and we need to be aware of the consequences.\u00a0 The good news is that we can mitigate and control the problem at a cellular level to improve overall health.<\/p>\n<p>All the best,<\/p>\n<p>Tom Schell, D.V.M.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Back in the days of high school biology class, we all learned the components of the cell.\u00a0 Chances are that most of us have forgotten what we learned back then and that is okay, but in today&#8217;s medical society this knowledge is becoming important whether it [&hellip;]<\/p>\n","protected":false},"author":2524,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":null,"stick-header-meta":null,"header-above-stick-meta":null,"header-main-stick-meta":null,"header-below-stick-meta":null,"astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[12],"tags":[],"class_list":["post-99378","post","type-post","status-publish","format-standard","hentry","category-equine-articles"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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